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LY2183240

产品号 L9044 公司名称 Sigma Aldrich
CAS号 874902-19-9 公司网站 http://www.sigmaaldrich.com
分子式 C17H17N5O 电 话 1-800-521-8956
分子量 307.34978 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 desiccated Chembase数据库ID: 128140

产品价格信息

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产品别名

标题
LY2183240
IUPAC标准名
N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1H-1,2,3,4-tetrazole-1-carboxamide
IUPAC传统名
N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1,2,3,4-tetrazole-1-carboxamide
别名
1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-
5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide

产品登记号

MDL号 MFCD08703123
CAS号 874902-19-9

产品性质

Empirical Formula (Hill Notation) C17H17N5O
纯度 ≥98% (HPLC)
溶解度 DMSO: >10 mg/mL
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H302
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
危险公开号 22
保存条件 desiccated
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Regioisomer 1-5 of LY2183240 is a potent inhibitor of anandamide uptake (IC50= 15 nM). The compound inhibits FAAH (IC50=2.1 nM) and some other brain serine proteases. After systemic administration to rodents, LY2182340 elevates brain anandamide levels and shows efficacy in a rodent model of persistent pain (ED50=1.37 mg/kg). Regioisomer 2-5 of LY2183240 is less active. The compound is more potent than N-(4-Hydroxyphenyl)-arachidonylamide (AM-404), which inhibits anandamide transport at IC50=1mM.
详细说明 (简体中文)
Biochem/physiol Actions
Regioisomer 1-5 of LY2183240 is a potent inhibitor of anandamide uptake (IC50= 15 nM). The compound inhibits FAAH (IC50=2.1 nM) and some other brain serine proteases. After systemic administration to rodents, LY2182340 elevates brain anandamide levels and shows efficacy in a rodent model of persistent pain (ED50=1.37 mg/kg). Regioisomer 2-5 of LY2183240 is less active. The compound is more potent than N-(4-Hydroxyphenyl)-arachidonylamide (AM-404), which inhibits anandamide transport at IC50=1mM.

参考文献