TPBM

• 产品号: T5202
• CAS号: 6466-43-9
• 分子式: C15H16N4O2S
• 分子量: 316.37814
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: TPBM
• IUPAC标准名: 8-[(benzylsulfanyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC传统名: 8-[(benzylsulfanyl)methyl]-1,3-dimethyl-7H-purine-2,6-dione
• 别名: Theophylline, 8-[(benzylthio)methyl]; 8-Benzylsulfanylmethyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; 8-[(Benzylthio)methyl]theophylline

产品登记号

• MDL号: MFCD11114397
• CAS号: 6466-43-9

产品性质

• Empirical Formula (Hill Notation): C15H16N4O2S
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 溶解度: DMSO: >5 mg/mL
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
TPBM is a potent inhibitor of estrogen receptor α via blocking ERα binding to consensus estrogen response element (cERE) DNA. Estrogen receptor α (ERα) plays an important role in several human cancers. Current ERα antagonists bind in the receptor ligand binding pocket and compete for binding with estrogenic ligands. TPBM instead inhibits ERα via binding to consensus estrogen response element (cERE) DNA. TPBM is not toxic to cells and does not effect estrogen-independent cell growth. TPBM does not act by chelating the zinc in ERs zinc fingers and differs from known ERα inhibitors.

详细说明 (简体中文)

Biochem/physiol Actions
TPBM is a potent inhibitor of estrogen receptor α via blocking ERα binding to consensus estrogen response element (cERE) DNA. Estrogen receptor α (ERα) plays an important role in several human cancers. Current ERα antagonists bind in the receptor ligand binding pocket and compete for binding with estrogenic ligands. TPBM instead inhibits ERα via binding to consensus estrogen response element (cERE) DNA. TPBM is not toxic to cells and does not effect estrogen-independent cell growth. TPBM does not act by chelating the zinc in ERs zinc fingers and differs from known ERα inhibitors.