Leptomycin A 来源于链霉菌 属

• 产品号: L6417
• CAS号: 87081-36-5
• 分子式: C32H46O6
• 分子量: 526.70404
• 纯 度: ~95% (HPLC)

产品别名

• 标题: Leptomycin A
• IUPAC标准名: 6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• IUPAC传统名: 6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• 别名: 19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid; Jildamycin

产品登记号

• MDL号: MFCD01711669
• CAS号: 87081-36-5

产品性质

• 生物来源: from Streptomyces sp.
• Empirical Formula (Hill Notation): C32H46O6
• 纯度: ~95% (HPLC)
• 运输包装: dry ice
• 外观: methanol solution
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• RID/ADR: UN 1230 3/PG 2
• 危险公开号: 11-23/24/25-39/23/24/25
• 安全公开号: 7-16-36/37-45
• 保存温度: -20°C
• 联合国危险货物等级: 3
• 联合国危险货物编号: 1230
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Leptomycins are antifungal antibiotics with unique unsaturated, branched-chain fatty acid structures.1, The physiochemical and biological properties of Leptomycins A and B are very similar.2, Both are considered to be specific inhibitors of nuclear export. The suggested inhibition mechanism involves the direct binding of leptomycins to CRM1 (Exportin-1), which is the main nuclear export protein. This blocks the binding of CRM1 to proteins containing a nuclear export signal (NES),3,4 and therefore prevents their export from the nucleus. Although more research on nuclear export inhibition has been performed using Leptomycin B, it has been shown that Leptomycin A has similar effects and can induce, for example, nuclear accumulation of wild-type ERK5.5Leptomycin A is also active against Schizosaccaromyces pombe and Mucor rouxianus.2

详细说明 (简体中文)

Biochem/physiol Actions
Leptomycins are antifungal antibiotics with unique unsaturated, branched-chain fatty acid structures.1, The physiochemical and biological properties of Leptomycins A and B are very similar.2, Both are considered to be specific inhibitors of nuclear export. The suggested inhibition mechanism involves the direct binding of leptomycins to CRM1 (Exportin-1), which is the main nuclear export protein. This blocks the binding of CRM1 to proteins containing a nuclear export signal (NES),3,4 and therefore prevents their export from the nucleus. Although more research on nuclear export inhibition has been performed using Leptomycin B, it has been shown that Leptomycin A has similar effects and can induce, for example, nuclear accumulation of wild-type ERK5.5Leptomycin A is also active against Schizosaccaromyces pombe and Mucor rouxianus.2