Raltitrexed monohydrate

• 产品号: R9156
• 分子式: C21H24N4O7S
• 分子量: 476.50286
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Raltitrexed monohydrate
• IUPAC标准名: (2S)-2-[(5-{methyl[(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid hydrate
• IUPAC传统名: (2S)-2-[(5-{methyl[(2-methyl-4-oxo-3H-quinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid hydrate
• 别名: ZD-1694; ICI-D-1694; L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)- monohydrate

产品登记号

• MDL号: MFCD12828867

产品性质

• Empirical Formula (Hill Notation): C21H22N4O6S · H2O
• 纯度: ≥98% (HPLC)
• 外观: off-white to light yellow solid
• 溶解度: H2O: ≥10 mg/mL
• 溶解度: DMSO: ≥40 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300-H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P201-P264-P301 + P310-P308 + P313
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 61-25
• 安全公开号: 53-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

详细说明 (简体中文)

Biochem/physiol Actions
Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.