Ramatroban

• 产品号: R0531
• CAS号: 116649-85-5
• 分子式: C21H21FN2O4S
• 分子量: 416.4658432
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Ramatroban
• IUPAC标准名: 3-[(3R)-3-(4-fluorobenzenesulfonamido)-2,3,4,9-tetrahydro-1H-carbazol-9-yl]propanoic acid
• IUPAC传统名: ramatroban
• 别名: (+)-(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid; BAY u3405

产品登记号

• CAS号: 116649-85-5
• MDL号: MFCD00887606

产品性质

• Empirical Formula (Hill Notation): C21H21FN2O4S
• 纯度: ≥98% (HPLC)
• 外观: white solid
• 溶解度: DMSO: ≥40 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36/37/39-45
• 保存温度: 2-8°C
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Ramatroban is used for the treatment of allergic rhinitis as an antagonist of the thromboxane receptor. It is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM. It is more potent at the DP2 receptor than the TP receptor by 4-5 fold. It is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.

详细说明 (简体中文)

Biochem/physiol Actions
Ramatroban is used for the treatment of allergic rhinitis as an antagonist of the thromboxane receptor. It is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM. It is more potent at the DP2 receptor than the TP receptor by 4-5 fold. It is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.