TUG-424

• 产品号: T6829
• CAS号: 1082058-99-8
• 分子式: C18H16O2
• 分子量: 264.31844
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: TUG-424
• IUPAC标准名: 3-{4-[2-(2-methylphenyl)ethynyl]phenyl}propanoic acid
• IUPAC传统名: 3-{4-[2-(2-methylphenyl)ethynyl]phenyl}propanoic acid
• 别名: 3-(4-(o-Tolylethynyl)phenyl)propanoic acid

产品登记号

• CAS号: 1082058-99-8
• MDL号: MFCD12912449

产品性质

• Empirical Formula (Hill Notation): C18H16O2
• 纯度: ≥98% (HPLC)
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H319-H410
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P273-P305 + P351 + P338-P501
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 36-50/53
• 安全公开号: 26-60-61
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.

详细说明 (简体中文)

Biochem/physiol Actions
TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.