Daptomycin

• 产品号: D2446
• CAS号: 103060-53-3
• 分子式: C72H101N17O26
• 分子量: 1620.67064
• 纯 度: ≥90% (HPLC)

产品别名

• 标题: Daptomycin
• IUPAC标准名: (3S)-3-{[(3S,6S,9R,15S,18R,21S,24R,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]carbamoyl}-3-[(2R)-3-carbamoyl-2-[(2S)-2-decanamido-3-(1H-indol-3-yl)propanamido]propanamido]propanoic acid
• IUPAC传统名: (3S)-3-{[(3S,6S,9R,15S,18R,21S,24R,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]carbamoyl}-3-[(2R)-3-carbamoyl-2-[(2S)-2-decanamido-3-(1H-indol-3-yl)propanamido]propanamido]propanoic acid
• 别名: Dapcin

产品登记号

• CAS号: 103060-53-3

产品性质

• Empirical Formula (Hill Notation): C72H101N17O26
• 纯度: ≥90% (HPLC)
• 溶解度: DMSO: soluble
• 溶解度: ethanol: soluble
• 溶解度: methanol: soluble
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Cyclic lipopeptide antibiotic effective against gram-positive bacteria. Derived from a fermentation product of Streptomyces sp. Its distinct mechanism of action, disrupting plamsa membrane function, makes it useful against resistant bacteria. Potential therapy for Staphylococcus aureus infections, including MRSA (methicillin-resistant Staphylococcus aureus).
Daptomycin disrupts plasma membrane function, which makes it useful against resistant bacteria. It is thought to cause rapid depolarization thereby inhibiting protein, DNA and RNA synthesis.
Application
Daptomycin is a cyclic lipopeptide antibiotic effective against gram-positive bacteria. It is derived from a fermentation product of Streptomyces sp. It is useful against resistant bacteria. It is a potential therapy for Staphylococcus aureus infections1, including MRSA (methicillin-resistant Staphylococcus aureus). It has also been studied as a potential therapy for Streptococcus pneumoniae infections 2. It has been used to study the impact of sarA on daptomycin susceptibility of Staphylococcus aureus.3

详细说明 (简体中文)

Biochem/physiol Actions
Cyclic lipopeptide antibiotic effective against gram-positive bacteria. Derived from a fermentation product of Streptomyces sp. Its distinct mechanism of action, disrupting plamsa membrane function, makes it useful against resistant bacteria. Potential therapy for Staphylococcus aureus infections, including MRSA (methicillin-resistant Staphylococcus aureus).
Daptomycin disrupts plasma membrane function, which makes it useful against resistant bacteria. It is thought to cause rapid depolarization thereby inhibiting protein, DNA and RNA synthesis.
Application
Daptomycin is a cyclic lipopeptide antibiotic effective against gram-positive bacteria. It is derived from a fermentation product of Streptomyces sp. It is useful against resistant bacteria. It is a potential therapy for Staphylococcus aureus infections1, including MRSA (methicillin-resistant Staphylococcus aureus). It has also been studied as a potential therapy for Streptococcus pneumoniae infections 2. It has been used to study the impact of sarA on daptomycin susceptibility of Staphylococcus aureus.3