RRD-251 hydrochloride

• 产品号: R7532
• CAS号: 72214-67-6
• 分子式: C8H9Cl3N2S
• 分子量: 271.59446
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: RRD-251 hydrochloride
• IUPAC标准名: {[(2,4-dichlorophenyl)methyl]sulfanyl}methanimidamide hydrochloride
• IUPAC传统名: [(2,4-dichlorophenyl)methyl]sulfanylmethanimidamide hydrochloride
• 别名: Rb/Raf-1 disruptor 251 hydrochloride; 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride; (2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride; S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride

产品登记号

• CAS号: 72214-67-6
• MDL号: MFCD00035047

产品性质

• Empirical Formula (Hill Notation): C8H8Cl2N2S· HCl
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: >2 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P261
• 危险公开号: 22-36/37/38
• 安全公开号: 26
• 保存条件: desiccated
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

详细说明 (简体中文)

Biochem/physiol Actions
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.