DCHC

• 产品号: D5569
• CAS号: 302953-06-6
• 分子式: C15H8Cl2O3
• 分子量: 307.12822
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: DCHC
• IUPAC标准名: 3-(2,4-dichlorophenyl)-7-hydroxy-4H-chromen-4-one
• IUPAC传统名: 3-(2,4-dichlorophenyl)-7-hydroxychromen-4-one
• 别名: 3-(2,4-Dichlorophenyl)-7-hydroxy-4H-chromen-4-one

产品登记号

• CAS号: 302953-06-6
• MDL号: MFCD01848896

产品性质

• Empirical Formula (Hill Notation): C15H8Cl2O3
• 纯度: ≥98% (HPLC)
• 外观: yellow solid
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25
• 安全公开号: 45
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
DCHC is a SIRT1 activator. It increases peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) expression, resulting in mitochondrial biogenesis. DCHC activates SIRT1 at low micromolar concentrations (5-10 μM) and increases SIRT1 activity at 100 μM. It is different from 5,7,4′-T in that it induces the activation of recombinant SIRT1, but does not increase SIRT1 expression.

详细说明 (简体中文)

Biochem/physiol Actions
DCHC is a SIRT1 activator. It increases peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) expression, resulting in mitochondrial biogenesis. DCHC activates SIRT1 at low micromolar concentrations (5-10 μM) and increases SIRT1 activity at 100 μM. It is different from 5,7,4′-T in that it induces the activation of recombinant SIRT1, but does not increase SIRT1 expression.