Ara-G hydrate

• 产品号: A4233
• CAS号: 38819-10-2(anhydrous)
• 分子式: C10H13N5O5
• 分子量: 283.24072
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Ara-G hydrate
• IUPAC标准名: 2-amino-9-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
• IUPAC传统名: 2-amino-9-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• 别名: 9-β-D-Arabinofuranosyl guanine hydrate

产品登记号

• CAS号: 38819-10-2(anhydrous)
• MDL号: MFCD00065486

产品性质

• Empirical Formula (Hill Notation): C10H13N5O5 · xH2O
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 22-36/37/38
• RTECS编号: MF8301000
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite.
Biochem/physiol Actions
Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.

详细说明 (简体中文)

Application
Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite.
Biochem/physiol Actions
Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.