Imidazolo-oxindole PKR inhibitor C16

• 产品号: I9785
• CAS号: 608512-97-6
• 分子式: C13H8N4OS
• 分子量: 268.29382
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Imidazolo-oxindole PKR inhibitor C16
• IUPAC标准名: 8-(1H-imidazol-4-ylmethylidene)-6H,7H,8H-[1,3]thiazolo[5,4-e]indol-7-one
• IUPAC传统名: 8-(1H-imidazol-4-ylmethylidene)-6H-[1,3]thiazolo[5,4-e]indol-7-one
• 别名: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

产品登记号

• MDL号: MFCD06735404
• CAS号: 608512-97-6

产品性质

• Empirical Formula (Hill Notation): C13H8N4OS
• 纯度: ≥98% (HPLC)
• 运输包装: wet ice
• 溶解度: DMSO: soluble12 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Other Notes
Protect from light and air.
Biochem/physiol Actions
Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.

详细说明 (简体中文)

Other Notes
Protect from light and air.
Biochem/physiol Actions
Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.