GW6471

• 产品号: G5045
• CAS号: 880635-03-0
• 分子式: C35H36F3N3O4
• 分子量: 619.6732496
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: GW6471
• IUPAC标准名: N-[(2S)-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-({4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl}amino)propyl]propanamide
• IUPAC传统名: N-[(2S)-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-({4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl}amino)propyl]propanamide
• 别名: N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide

产品登记号

• CAS号: 880635-03-0
• MDL号: MFCD07784503
• PubChem SID: 24724489

产品性质

• Empirical Formula (Hill Notation): C35H36F3N3O4
• 纯度: ≥98% (HPLC)
• 外观: off-white to light yellow solid
• 溶解度: DMSO: >10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.

详细说明 (简体中文)

Biochem/physiol Actions
GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.