RF9 trifluoroacetate salt

• 产品号: R4282
• CAS号: 876310-60-0(freebase)
• 分子式: C28H39F3N6O5
• 分子量: 596.6416696
• 纯 度: ≥97% (HPLC)

产品别名

• 标题: RF9 trifluoroacetate salt
• IUPAC标准名: (2S)-5-carbamimidamido-N-[(1S)-1-carbamoyl-2-phenylethyl]-2-[(3R,5S,7s)-adamantan-1-ylformamido]pentanamide; trifluoroacetic acid
• IUPAC传统名: (2S)-5-carbamimidamido-N-[(1S)-1-carbamoyl-2-phenylethyl]-2-[(3R,5S,7s)-adamantan-1-ylformamido]pentanamide; trifluoroacetic acid
• 别名: 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt

产品登记号

• CAS号: 876310-60-0(freebase)

产品性质

• Empirical Formula (Hill Notation): C26H38N6O3 · xC2HF3O2
• 纯度: ≥97% (HPLC)
• 溶解度: H2O: soluble20 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.

详细说明 (简体中文)

Biochem/physiol Actions
RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.