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Combretastatin A4

产品号 C7744 公司名称 Sigma Aldrich
CAS号 117048-59-6 公司网站 http://www.sigmaaldrich.com
分子式 C18H20O5 电 话 1-800-521-8956
分子量 316.3484 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 126674

产品价格信息

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产品别名

标题
Combretastatin A4
IUPAC标准名
2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
IUPAC传统名
combretastatin A-4
别名
CA4
2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene

产品登记号

CAS号 117048-59-6
MDL号 MFCD03453309

产品性质

Empirical Formula (Hill Notation) C18H20O5
纯度 ≥98% (HPLC)
外观 off-white powder
溶解度 DMSO: >10 mg/mL
GHS危险品标识 GHS05
GHS危险品标识 GHS06
GHS警示词 Danger
GHS危险声明 H301-H311-H318-H331
欧盟危险性物质标志 有毒(Toxic) 有毒(Toxic) (T)
MSDS下载 下载链接
个人保护装置 Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS警示性声明 P261-P280-P301 + P310-P305 + P351 + P338-P311
RID/ADR UN 2811 6.1/PG 3
危险公开号 23/24/25-41
安全公开号 26-36/37-39-45
保存温度 -20°C
联合国危险货物等级 6.1
联合国危险货物编号 2811
联合国危险货物包装类别(PG) 3
德国WGK号 2

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.
详细说明 (简体中文)
Biochem/physiol Actions
Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.

参考文献