BI-78D3

• 产品号: B3063
• CAS号: 883065-90-5
• 分子式: C13H9N5O5S2
• 分子量: 379.37106
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: BI-78D3
• IUPAC标准名: 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-4H-1,2,4-triazol-3-ol
• IUPAC传统名: 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,2,4-triazol-3-ol
• 别名: 4-(2,3-Dihydrobenzol[b][1,4]dioxin-6-yl)-5-(5-nitrothiazol-2-ylthio)-4H-1,2,4-triazol-3-ol

产品登记号

• CAS号: 883065-90-5
• MDL号: MFCD12912396

产品性质

• Empirical Formula (Hill Notation): C13H9N5O5S2
• 纯度: ≥98% (HPLC)
• 外观: tan powder
• 溶解度: DMSO: >10 mg/mL
• 保存条件: desiccated
• 保存温度: -20°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
BI-78D3 is a substrate competitive inhibitor of JNK. JNK′s binds to JNK-interacting protein-1 (JIP1) (scaffolding protein) through high affinity D-domain on JIP1. This interaction is needed to place JNK next to target protein. BI-78D3 is a mimetic of a critical peptide structure of JIP1 which binds to JNK away from ATP binding domain preventing JIP1 JNK interaction thus acting as a substrate competitive inhibitor both in vitro and in vivo. The compound represents a growing number of modern kinase inhibitors acting at protein protein interacting areas (scaffolding) rather than ATP binding pockets.

详细说明 (简体中文)

Biochem/physiol Actions
BI-78D3 is a substrate competitive inhibitor of JNK. JNK′s binds to JNK-interacting protein-1 (JIP1) (scaffolding protein) through high affinity D-domain on JIP1. This interaction is needed to place JNK next to target protein. BI-78D3 is a mimetic of a critical peptide structure of JIP1 which binds to JNK away from ATP binding domain preventing JIP1 JNK interaction thus acting as a substrate competitive inhibitor both in vitro and in vivo. The compound represents a growing number of modern kinase inhibitors acting at protein protein interacting areas (scaffolding) rather than ATP binding pockets.