Aculeacin A

• 产品号: A7603
• CAS号: 58814-86-1
• 分子式: C50H81N7O16
• 分子量: 1036.21544
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: Aculeacin A
• IUPAC标准名: N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0^9,^1^3]heptacosan-18-yl]hexadecanamide
• IUPAC传统名: N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0^9,^1^3]heptacosan-18-yl]hexadecanamide

产品登记号

• MDL号: MFCD01674009
• CAS号: 58814-86-1

产品性质

• 生物来源: from Aspergillus aculeatus
• Empirical Formula (Hill Notation): C50H81N7O16
• 纯度: ≥95% (HPLC)
• 运输包装: wet ice
• 溶解度: DMSO: soluble10 mg/mL
• 溶解度: DMF: soluble
• 溶解度: ethanol: soluble
• 溶解度: methanol: soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: AU2980000
• 保存温度: -20°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase.
Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β-glucan by selective blockage of β(1→3) glucan synthase.
Application
Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae 1, the inhibition of Candida albicans2, and the morphogenetic transformation of Candida albicans when treated 3.

详细说明 (简体中文)

Biochem/physiol Actions
Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase.
Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β-glucan by selective blockage of β(1→3) glucan synthase.
Application
Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae 1, the inhibition of Candida albicans2, and the morphogenetic transformation of Candida albicans when treated 3.