GGTI-2133

• 产品号: G5294
• 分子式: C29H29F3N4O5
• 分子量: 570.5595696
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: GGTI-2133
• IUPAC标准名: (2S)-2-({4-[(1H-imidazol-4-ylmethyl)amino]-2-(naphthalen-1-yl)phenyl}formamido)-4-methylpentanoic acid; trifluoroacetic acid
• IUPAC传统名: (2S)-2-({4-[(1H-imidazol-4-ylmethyl)amino]-2-(naphthalen-1-yl)phenyl}formamido)-4-methylpentanoic acid; trifluoroacetic acid
• 别名: N-[[4-(Imidazol-4-yl)methylamino]-2-(1-naphthyl)benzoyl]leucine trifluoroacetate salt

产品登记号

• MDL号: MFCD07776925
• PubChem SID: 24724491

产品性质

• Empirical Formula (Hill Notation): C27H28N4O3 · C2HF3O2
• 纯度: ≥98% (HPLC)
• 运输包装: wet ice
• 相关基因信息: human ... FNTA(2339), PGGT1B(5229)
• 外观: white solid
• 熔点: 103-118.5 °C
• 溶解度: DMSO: soluble25 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
GGTI-2133 is a cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I; IC50 = 38 nM) with a 140-fold selectivity over farnesyltransferase (FTase; IC50 = 5.4 μM).

详细说明 (简体中文)

Biochem/physiol Actions
GGTI-2133 is a cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I; IC50 = 38 nM) with a 140-fold selectivity over farnesyltransferase (FTase; IC50 = 5.4 μM).