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DAPT
产品号	D5942	公司名称	Sigma Aldrich
CAS号	208255-80-5	公司网站	http://www.sigmaaldrich.com
分子式	C23H26F2N2O4	电话	1-800-521-8956
分子量	432.4603464	传真
纯度	≥98% (HPLC)	电子邮件
保存		Chembase数据库ID: 154236

产品价格信息

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产品别名

标题

DAPT

IUPAC标准名

tert-butyl (2R)-2-[(2S)-2-[2-(3,5-difluorophenyl)acetamido]propanamido]-2-phenylacetate

IUPAC传统名

tert-butyl (2R)-2-[(2S)-2-[2-(3,5-difluorophenyl)acetamido]propanamido]-2-phenylacetate

别名

LY-374973

N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester

产品登记号

PubChem SID	24893987
CAS号	208255-80-5
MDL号	MFCD04974585

产品性质

Empirical Formula (Hill Notation)	C23H26F2N2O4
纯度	≥98% (HPLC)
相关基因信息	human ... APH1A(51107), APH1B(83464), NCSTN(23385), NOTCH1(4851), NOTCH2(4853), NOTCH3(4854), NOTCH4(4855), PSEN1(5663), PSEN2(5664), PSENEN(55851)mouse ... Aph1a(226548), Aph1b(208117), Ncstn(59287), Notch1(18128), Notch2(18129), Notch3(18131), Notch4(18132), Psen1(19164), Psen2(19165), Psenen(66340)rat ... Aph1a(365872), Aph1b(300802), Ncstn(289231), Notch1(25496), Notch2(29492), Notch3(56761), Notch4(406162), Psen1(29192), Psen2(81751), Psenen(292788)
外观	white solid
溶解度	DMSO: ~18 mg/mL
MSDS下载	下载链接
个人保护装置	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度	2-8°C
德国WGK号	3

产品详细信息

详细说明 (简体中文)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. As an inhibitor of Notch, DAPT may advance studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE). Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4.

详细说明 (English)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. As an inhibitor of Notch, DAPT may advance studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE). Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4.