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GSK1016790A

产品号 G0798 公司名称 Sigma Aldrich
CAS号 942206-85-1 公司网站 http://www.sigmaaldrich.com
分子式 C28H32Cl2N4O6S2 电 话 1-800-521-8956
分子量 655.61288 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 154220

产品价格信息

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产品别名

标题
GSK1016790A
IUPAC标准名
N-[(2S)-1-{4-[(2S)-2-(2,4-dichlorobenzenesulfonamido)-3-hydroxypropanoyl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide
IUPAC传统名
N-[(2S)-1-{4-[(2S)-2-(2,4-dichlorobenzenesulfonamido)-3-hydroxypropanoyl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide
别名
(N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide

产品登记号

CAS号 942206-85-1
MDL号 MFCD12912413

产品性质

Empirical Formula (Hill Notation) C28H32Cl2N4O6S2
纯度 ≥98% (HPLC)
外观 white solid
溶解度 DMSO: >10 mg/mL
MSDS下载 下载链接
保存温度 -20°C
德国WGK号 1

产品详细信息

详细说明 (English)
Biochem/physiol Actions
GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300 fold more potent than 4a-PDD (Cat. No. P8014).
详细说明 (简体中文)
Biochem/physiol Actions
GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300 fold more potent than 4a-PDD (Cat. No. P8014).

参考文献