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Prostratin

产品号 P0077 公司名称 Sigma Aldrich
CAS号 60857-08-1 公司网站 http://www.sigmaaldrich.com
分子式 C22H30O6 电 话 1-800-521-8956
分子量 390.47 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 129142

产品价格信息

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产品别名

标题
Prostratin
IUPAC标准名
(1R,2S,6R,10S,11R,13S,15R)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dien-13-yl acetate
IUPAC传统名
prostratin
别名
NSC 623310
CCRIS 6292
12-Deoxyphorbol-13-acetate

产品登记号

MDL号 MFCD00674138
CAS号 60857-08-1

产品性质

Empirical Formula (Hill Notation) C22H30O6
纯度 ≥98% (HPLC)
外观 white powder
溶解度 DMSO: soluble30 mg/mL
MSDS下载 下载链接
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors.
详细说明 (简体中文)
Biochem/physiol Actions
Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors.

参考文献