17-(Allylamino)-17-demethoxygeldanamycin

• 产品号: A8476
• CAS号: 75747-14-7
• 分子式: C31H43N3O8
• 分子量: 585.68842
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: 17-(Allylamino)-17-demethoxygeldanamycin
• IUPAC标准名: (8S,9S,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• IUPAC传统名: (8S,9S,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• 别名: 17-AAG; CP 127374; 17-Demethoxy-17-allylamino geldanamycin; Tanespimycin; 17-(Allylamino)geldanamycin; Geldanamycin,17-demethoxy-17-(2-propenylamino)-; NSC 330507

产品登记号

• CAS号: 75747-14-7
• MDL号: MFCD04973892

产品性质

• Empirical Formula (Hill Notation): C31H43N3O8
• 纯度: ≥98% (HPLC)
• 运输包装: wet ice
• 外观: solid
• 溶解度: DMSO: soluble
• 溶解度: methanol: soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
Application
17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

详细说明 (简体中文)

Biochem/physiol Actions
Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
Application
17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.