Apicidin

• 产品号: A8851
• CAS号: 183506-66-3
• 分子式: C34H49N5O6
• 分子量: 623.78276
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Apicidin
• IUPAC标准名: (3S,6S,15aR)-9-(butan-2-yl)-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)-tetradecahydro-1H-pyrido[1,2-a]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrone
• IUPAC传统名: (3S,6S,15aR)-6-[(1-methoxyindol-3-yl)methyl]-3-(6-oxooctyl)-9-(sec-butyl)-decahydro-2H-pyrido[1,2-a]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrone
• 别名: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]

产品登记号

• MDL号: MFCD03452661
• CAS号: 183506-66-3

产品性质

• 生物来源: from microbial
• Empirical Formula (Hill Notation): C34H49N5O6
• 纯度: ≥98% (HPLC)
• 运输包装: wet ice
• 外观: solid
• 溶解度: DMSO: ~1 mg/mL
• 溶解度: acetonitrile: ~1 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300-H310-H330
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P260-P264-P280-P284-P302 + P350-P310
• RID/ADR: UN 2811 6.1/PG 2
• 危险公开号: 26/27/28
• 安全公开号: 22-26-36/37/39-45
• 保存温度: -20°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Potent (nM) cell permeable inhibitor of histone deacetylase. Also, exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. In addition, it induces selective changes in the expression of p21 and gelsolin.

详细说明 (简体中文)

Biochem/physiol Actions
Potent (nM) cell permeable inhibitor of histone deacetylase. Also, exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. In addition, it induces selective changes in the expression of p21 and gelsolin.