Ro 48-8071 fumarate

• 产品号: R2278
• CAS号: 189197-69-1
• 分子式: C27H31BrFNO6
• 分子量: 564.4405432
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Ro 48-8071 fumarate
• IUPAC标准名: but-2-enedioic acid; {6-[4-(4-bromobenzoyl)-3-fluorophenoxy]hexyl}(methyl)(prop-2-en-1-yl)amine
• IUPAC传统名: C23H27BrFNO2; butenedioic acid
• 别名: [4′-[6-(Allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate (1:1)

产品登记号

• MDL号: MFCD05865242
• CAS号: 189197-69-1

产品性质

• Empirical Formula (Hill Notation): C23H27NO2BrF · C4H4O4
• 纯度: ≥98% (HPLC)
• 外观: white solid
• 熔点: 90-92.7 °C
• 溶解度: H2O: >5 mg/mL at ~60 °C
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Orally active 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop.

详细说明 (简体中文)

Biochem/physiol Actions
Orally active 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop.