Y-27632 dihydrochloride

• 产品号: Y0503
• CAS号: 129830-38-2
• 分子式: C14H25Cl2N3O2
• 分子量: 338.2732
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Y-27632 dihydrochloride
• IUPAC标准名: (1R,4r)-4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide hydrate dihydrochloride
• IUPAC传统名: (1R,4r)-4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide hydrate dihydrochloride
• 别名: (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride

产品登记号

• MDL号: MFCD03490488
• CAS号: 129830-38-2
• PubChem SID: 24277699

产品性质

• Empirical Formula (Hill Notation): C14H21N3O · 2HCl
• 纯度: ≥98% (HPLC)
• 相关基因信息: human ... ROCK1(6093), ROCK2(9475)
• 外观: white to beige powder
• 溶解度: H2O: soluble14 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302 + H312 + H332
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P280
• 危险公开号: 20/21/22
• 安全公开号: 36
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Legal Information
Sold under license from Mitsubishi Pharma Corporation
Biochem/physiol Actions
Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.

详细说明 (简体中文)

Legal Information
Sold under license from Mitsubishi Pharma Corporation
Biochem/physiol Actions
Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.