IMS2186

• 产品号: I7160
• CAS号: 1031206-36-6
• 分子式: C18H16O4
• 分子量: 296.31724
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: IMS2186
• IUPAC标准名: 3-[(3-hydroxy-4-methoxyphenyl)methylidene]-6-methyl-3,4-dihydro-2H-1-benzopyran-4-one
• IUPAC传统名: 3-[(3-hydroxy-4-methoxyphenyl)methylidene]-6-methyl-2H-1-benzopyran-4-one
• 别名: 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

产品登记号

• CAS号: 1031206-36-6
• MDL号: MFCD12912419

产品性质

• Empirical Formula (Hill Notation): C18H16O4
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H400
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P273
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 50/53
• 安全公开号: 60-61
• 保存条件: desiccated
• 保存温度: room temp
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.

详细说明 (简体中文)

Biochem/physiol Actions
IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.