5HPP-33

• 产品号: H9415
• CAS号: 105624-86-0
• 分子式: C20H21NO3
• 分子量: 323.38564
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: 5HPP-33
• IUPAC标准名: 2-[2,6-bis(propan-2-yl)phenyl]-5-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione
• IUPAC传统名: 2-(2,6-diisopropylphenyl)-5-hydroxyisoindole-1,3-dione
• 别名: 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione; 2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione

产品登记号

• CAS号: 105624-86-0
• MDL号: MFCD03085294

产品性质

• Empirical Formula (Hill Notation): C20H21NO3
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H410
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P273-P501
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 50/53
• 安全公开号: 60-61
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).

详细说明 (简体中文)

Biochem/physiol Actions
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).