Penicillic acid

• 产品号: P0063
• CAS号: 90-65-3
• 分子式: C8H10O4
• 分子量: 170.1626
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Penicillic acid
• IUPAC标准名: 3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid
• IUPAC传统名: penicillic acid
• 别名: PA; 3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid

产品登记号

• MDL号: MFCD00004365
• CAS号: 90-65-3
• EC号: 202-008-1

产品性质

• Empirical Formula (Hill Notation): C8H10O4
• 纯度: ≥98% (HPLC)
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: ≤10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• RTECS编号: MM2625000
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species. It is used to study FasL-induced apoptosis and cell viability in Burkitt′s lymphoma Raji cells1. It is used to study bacterial bioluminescence bioassays2 and genotoxicity of hepatocytes3.
Biochem/physiol Actions
Penicillic acid induces single and double strand DNA breaks. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme. It also inhibits muscle aldose dehydrogenase, alcohol dehydrogenase, and lactate dehydrogenase. Penicillic acid inhibits fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex1.
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species. It induces single and double strand DNA breaks. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme. It also inhibits muscle aldose dehydrogenase, alcohol dehydrogenase, and lactate dehydrogenase.

详细说明 (简体中文)

Application
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species. It is used to study FasL-induced apoptosis and cell viability in Burkitt′s lymphoma Raji cells1. It is used to study bacterial bioluminescence bioassays2 and genotoxicity of hepatocytes3.
Biochem/physiol Actions
Penicillic acid induces single and double strand DNA breaks. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme. It also inhibits muscle aldose dehydrogenase, alcohol dehydrogenase, and lactate dehydrogenase. Penicillic acid inhibits fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex1.
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species. It induces single and double strand DNA breaks. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme. It also inhibits muscle aldose dehydrogenase, alcohol dehydrogenase, and lactate dehydrogenase.