(4S)-4-Hydroxy-L-isoleucine

• 产品号: 50118
• CAS号: 55399-93-4
• 分子式: C6H13NO3
• 分子量: 147.17232
• 纯 度: ≥98.0% (TLC)

产品别名

• 标题: (4S)-4-Hydroxy-L-isoleucine
• IUPAC标准名: (2S,3R)-2-amino-4-hydroxy-3-methylpentanoic acid
• IUPAC传统名: (2S,3R)-2-amino-4-hydroxy-3-methylpentanoic acid
• 别名: (2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acid; HIL; 4-HYDROXYISOLEUCINE

产品登记号

• Beilstein号: 4128096
• MDL号: MFCD06799350
• CAS号: 55399-93-4

产品性质

• 生物来源: from fenugreek seed
• Empirical Formula (Hill Notation): C6H13NO3
• 纯度: ≥98.0% (TLC)
• 闪点: 147 °C
• 闪点: 296.6 °F
• 比旋光度: [α]/D +31.0±1.5°, c = 1 in H2O
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
(4S)-4-Hydroxy-L-isoleucine (HIL) is a non-proteinogenic α amino acid produced by the activity of bacterial isoleucine dioxygenase(s). (2S,3R,4S)-HIL is being studied to understand its insulinotropic (anti-diabetic) and anti-obesity effects.
4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secretion from pancreatic cells. HIL activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. HIL reduces plasma levels of triglycerides, free fatty acids and cholesterol.

详细说明 (English)

Biochem/physiol Actions
(4S)-4-Hydroxy-L-isoleucine (HIL) is a non-proteinogenic α amino acid produced by the activity of bacterial isoleucine dioxygenase(s). (2S,3R,4S)-HIL is being studied to understand its insulinotropic (anti-diabetic) and anti-obesity effects.
4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secretion from pancreatic cells. HIL activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. HIL reduces plasma levels of triglycerides, free fatty acids and cholesterol.