K-252a

• 产品号: K2015
• CAS号: 99533-80-9
• 分子式: C27H21N3O5
• 分子量: 467.47274
• 纯 度: >98%

产品别名

• 标题: K-252a
• IUPAC标准名: methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^1^5,^1^8.0^2,^6.0^7,^2^7.0^8,^1^3.0^1^9,^2^6.0^2^0,^2^5]octacosa-1(26),2(6),7(27),8,10,12,20(25),21,23-nonaene-16-carboxylate
• IUPAC传统名: methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^1^5,^1^8.0^2,^6.0^7,^2^7.0^8,^1^3.0^1^9,^2^6.0^2^0,^2^5]octacosa-1(26),2(6),7(27),8,10,12,20(25),21,23-nonaene-16-carboxylate

产品登记号

• CAS号: 99533-80-9
• MDL号: MFCD00161522
• EC号: 200-664-3

产品性质

• 生物来源: from Nonomuraea longicatena
• Empirical Formula (Hill Notation): C27H21N3O5
• 纯度: >98%
• 运输包装: dry ice
• 相关基因信息: human ... NTRK1(4914)rat ... Prkca(24680)
• 闪点: 87 °C
• 闪点: 188.6 °F
• 个人保护装置: Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• 保存温度: -20°C
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Physical form
Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).
Biochem/physiol Actions
K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor.1 At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures.2 K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c.3 K-252a improves psoriasis in a SCID mouse-human skin model4 and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.5

详细说明 (简体中文)

Physical form
Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).
Biochem/physiol Actions
K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor.1 At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures.2 K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c.3 K-252a improves psoriasis in a SCID mouse-human skin model4 and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.5