LP 12 hydrochloride hydrate

• 产品号: L3169
• 分子式: C32H42ClN3O2
• 分子量: 536.14778
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: LP 12 hydrochloride hydrate
• IUPAC标准名: 6-[4-(2-phenylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide hydrate hydrochloride
• IUPAC传统名: 6-[4-(2-phenylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide hydrate hydrochloride
• 别名: 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1- piperazinehexanamide hydrochloride

产品登记号

• MDL号: MFCD11114387

产品性质

• Empirical Formula (Hill Notation): C32H39N3O·HCl · xH2O
• 纯度: ≥98% (HPLC)
• 外观: off-white solid
• 溶解度: DMSO: >5 mg/mL
• 溶解度: H2O: soluble6 mg/mL
• GHS警示词: Warning
• GHS危险声明: H319
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS警示性声明: P305 + P351 + P338
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
LP 12 dihydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and 1464 nM, respectively. It also displays selectivity over D2, 1723; over 5-HT1A, 468; over 5-HT2A, 11261; and high potency. Sigma has added LP 44 (L9793) which shows significantly lower D2 selectivity (7.3 nM/0.22 nM for 33-fold), lower selectivity over 5-HT1A, 240; and over 5-HT2A, 1482. LP 12 and LP 44 seem to share a common intermediate.

详细说明 (简体中文)

Biochem/physiol Actions
LP 12 dihydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and 1464 nM, respectively. It also displays selectivity over D2, 1723; over 5-HT1A, 468; over 5-HT2A, 11261; and high potency. Sigma has added LP 44 (L9793) which shows significantly lower D2 selectivity (7.3 nM/0.22 nM for 33-fold), lower selectivity over 5-HT1A, 240; and over 5-HT2A, 1482. LP 12 and LP 44 seem to share a common intermediate.