QS11 hydrate

• 产品号: Q4972
• CAS号: 944328-88-5(anhydrous)
• 分子式: C36H35N5O3
• 分子量: 585.6948
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: QS11 hydrate
• IUPAC标准名: (2S)-2-{[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-9H-purin-6-yl]amino}-3-phenylpropan-1-ol hydrate
• IUPAC传统名: (2S)-2-{[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino}-3-phenylpropan-1-ol hydrate
• 别名: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate

产品登记号

• CAS号: 944328-88-5(anhydrous)
• MDL号: MFCD12912439

产品性质

• Empirical Formula (Hill Notation): C36H33N5O2 · xH2O
• 纯度: ≥98% (HPLC)
• 外观: white powder
• 溶解度: DMSO: >10 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell morphology, motility, proliferation, and differentiation during development. The GTPase activating protein of ADP-ribosylation factors (ARFGAPs) regulates the small GTPase ADP-ribosylation factors (ARFs) that mediate a number of biological processes, including vesicle trafficking and cytoskeleton reorganization. QS-11 binds and inhibits GTPase activating protein of ADP-ribosylation factor1 (ARFGAP1). Inhibition of ARFGAPs increases the level of activated ARF and subsequent β-catenin translocation leading to pathway activation.

详细说明 (简体中文)

Biochem/physiol Actions
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell morphology, motility, proliferation, and differentiation during development. The GTPase activating protein of ADP-ribosylation factors (ARFGAPs) regulates the small GTPase ADP-ribosylation factors (ARFs) that mediate a number of biological processes, including vesicle trafficking and cytoskeleton reorganization. QS-11 binds and inhibits GTPase activating protein of ADP-ribosylation factor1 (ARFGAP1). Inhibition of ARFGAPs increases the level of activated ARF and subsequent β-catenin translocation leading to pathway activation.