PAC-1

• 产品号: P0115
• CAS号: 315183-21-2
• 分子式: C23H28N4O2
• 分子量: 392.49402
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: PAC-1
• IUPAC标准名: 2-(4-benzylpiperazin-1-yl)-N'-{[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
• IUPAC传统名: 2-(4-benzylpiperazin-1-yl)-N'-{[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
• 别名: 1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide; (4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide

产品登记号

• CAS号: 315183-21-2
• MDL号: MFCD03302441

产品性质

• Empirical Formula (Hill Notation): C23H28N4O2
• 纯度: ≥98% (HPLC)
• 外观: white solid
• 溶解度: DMSO: ≥10 mg/mL
• 溶解度: deionized water: ≤2 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335-H400
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P273-P305 + P351 + P338
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 22-36/37/38-50/53
• 安全公开号: 26-36/37-60-61
• 保存温度: room temp
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.

详细说明 (简体中文)

Biochem/physiol Actions
PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.