Metyrapone

• 产品号: M2696
• CAS号: 54-36-4
• 分子式: C14H14N2O
• 分子量: 226.27376
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Metyrapone
• IUPAC标准名: 2-methyl-1,2-bis(pyridin-3-yl)propan-1-one
• IUPAC传统名: metyrapone
• 别名: 2-甲基-1,2-二-3-吡啶基-1-丙酮; 美替拉酮; 2-Methyl-1,2-di-3-pyridyl-1-propanone; Su-4885; Metyrapone

产品登记号

• Beilstein号: 163023
• CAS号: 54-36-4
• EC号: 200-206-2
• MDL号: MFCD00006397

产品性质

• Empirical Formula (Hill Notation): C14H14N2O
• 纯度: ≥98% (HPLC)
• 外观: solid
• 闪点: >110 °C
• 闪点: >230 °F
• 熔点: 52-55 °C(lit.)
• 溶解度: H2O: <2 mg/mL
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 22-36/37/38
• RTECS编号: UC3050000
• 安全公开号: 26
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.

详细说明 (简体中文)

Biochem/physiol Actions
Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.