Aprindine 盐酸盐

• 产品号: A7606
• CAS号: 33237-74-0
• 分子式: C22H31ClN2
• 分子量: 358.94794
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Aprindine hydrochloride
• IUPAC标准名: {3-[(2,3-dihydro-1H-inden-2-yl)(phenyl)amino]propyl}diethylamine hydrochloride
• IUPAC传统名: aprindine hydrochloride
• 别名: N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride; Amidonal

产品登记号

• EC号: 251-418-7
• MDL号: MFCD01698392
• CAS号: 33237-74-0

产品性质

• Empirical Formula (Hill Notation): C22H30N2 · HCl
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: H2O: >10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 22-36/37/38
• RTECS编号: TX7386000
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase.
Biochem/physiol Actions
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.

详细说明 (简体中文)

Application
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase.
Biochem/physiol Actions
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.