SPD304

• 产品号: S1697
• 分子式: C32H34Cl2F3N3O2
• 分子量: 620.5324696
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: SPD304
• IUPAC标准名: 6,7-dimethyl-3-{[methyl({2-[methyl({1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl}methyl)amino]ethyl})amino]methyl}-4H-chromen-4-one dihydrochloride
• IUPAC传统名: 6,7-dimethyl-3-{[methyl({2-[methyl({1-[3-(trifluoromethyl)phenyl]indol-3-yl}methyl)amino]ethyl})amino]methyl}chromen-4-one dihydrochloride
• 别名: 6,7-Dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-(4H-1-Benzopyran-4-one dihydrochloride; 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-(4H-1-Benzopyran-4-one 二盐酸盐; SPD00000304

产品登记号

• MDL号: MFCD09265259
• PubChem SID: 24724602

产品性质

• Empirical Formula (Hill Notation): C32H32F3N3O2 · 2HCl
• 纯度: ≥98% (HPLC)
• 相关基因信息: human ... TNF(7124)mouse ... TNF(21926)rat ... TNF(24835)
• 外观: white solid
• 溶解度: H2O: >5 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM.

详细说明 (简体中文)

Biochem/physiol Actions
SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM.