RP-107

• 产品号: R3405
• CAS号: 496864-15-4
• 分子式: C16H17N3O
• 分子量: 267.32568
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: RP-107
• IUPAC标准名: 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
• IUPAC传统名: 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
• 别名: 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine

产品登记号

• CAS号: 496864-15-4
• MDL号: MFCD04973541

产品性质

• Empirical Formula (Hill Notation): C16H17N3O
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335-H413
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 22-36/37/38
• 安全公开号: 26-36/37
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC50 = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

详细说明 (简体中文)

Biochem/physiol Actions
RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC50 = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.