AD 198

• 产品号: A9481
• CAS号: 98983-21-2
• 分子式: C39H43NO12
• 分子量: 717.75822
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: AD 198
• IUPAC标准名: 2-[(2S,4S)-4-{[(2R,4S,5S,6S)-4-(benzylamino)-5-hydroxy-6-methyloxan-2-yl]oxy}-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl]-2-oxoethyl pentanoate
• IUPAC传统名: 2-[(2S,4S)-4-{[(2R,4S,5S,6S)-4-(benzylamino)-5-hydroxy-6-methyloxan-2-yl]oxy}-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-oxoethyl pentanoate
• 别名: N-Benzyladriamycin-14-valerate

产品登记号

• CAS号: 98983-21-2

产品性质

• Empirical Formula (Hill Notation): C39H43NO12
• 纯度: ≥98% (HPLC)
• 外观: red solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: insoluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: SA3697000
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
AD 198 is a PKC-delta activator. Phospholipid scramblase 3 (PLS3) is an enzyme that plays a critical role in mitochondrial morphology, functions, and apoptotic response. During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitochondria and phosphorylates PLS3. Used to show that PLS3 is a critical downstream effector of PKC-delta in AD 198-induced apoptosis.

详细说明 (简体中文)

Biochem/physiol Actions
AD 198 is a PKC-delta activator. Phospholipid scramblase 3 (PLS3) is an enzyme that plays a critical role in mitochondrial morphology, functions, and apoptotic response. During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitochondria and phosphorylates PLS3. Used to show that PLS3 is a critical downstream effector of PKC-delta in AD 198-induced apoptosis.