CHPG

• 产品号: C7743
• CAS号: 170846-74-9
• 分子式: C8H8ClNO3
• 分子量: 201.60702
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: CHPG
• IUPAC标准名: 2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
• IUPAC传统名: amino(2-chloro-5-hydroxyphenyl)acetic acid
• 别名: α-amino-2-chloro-5-hydroxybenzeneacetic acid; (RS)-2-Chloro-5-hydroxyphenylglycine; (RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid

产品登记号

• CAS号: 170846-74-9
• MDL号: MFCD01321059

产品性质

• Empirical Formula (Hill Notation): C8H8ClNO3
• 纯度: ≥98% (HPLC)
• 外观: white solid
• 外观: white solid
• 溶解度: DMSO: ≥10 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
CHPG is a selective, potent mGluR5 agonist. CHO cells expressing mGluR5 (but not those expressing mGluR1) are activated by CHPG. In vivo, CHPG stimulates thalamic neurons and is antagonized by MPEP (selective mGluR5 antagonist); CHPG potentiates NMDA and AMPA responses in spinal cord and produces oscillations in intracellular calcium in dorsal root ganglion cells.

详细说明 (简体中文)

Biochem/physiol Actions
CHPG is a selective, potent mGluR5 agonist. CHO cells expressing mGluR5 (but not those expressing mGluR1) are activated by CHPG. In vivo, CHPG stimulates thalamic neurons and is antagonized by MPEP (selective mGluR5 antagonist); CHPG potentiates NMDA and AMPA responses in spinal cord and produces oscillations in intracellular calcium in dorsal root ganglion cells.