III-31-C

• 产品号: C0619
• CAS号: 398515-96-3
• 分子式: C35H52N4O7
• 分子量: 640.80998
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: III-31-C
• IUPAC标准名: methyl (2S)-2-[(2S)-2-({benzyl[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-4-phenylbutyl]carbamoyl}amino)-4-methylpentanamido]-3-methylbutanoate
• IUPAC传统名: methyl (2S)-2-[(2S)-2-({benzyl[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl]carbamoyl}amino)-4-methylpentanamido]-3-methylbutanoate
• 别名: N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester; WPE-III-31-C

产品登记号

• CAS号: 398515-96-3

产品性质

• Empirical Formula (Hill Notation): C35H52N4O7
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: ≥9 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存条件: desiccated
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor that binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors that affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.

详细说明 (简体中文)

Biochem/physiol Actions
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor that binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors that affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.