CPTH2

• 产品号: C9873
• CAS号: 357649-93-5
• 分子式: C14H14ClN3S
• 分子量: 291.79906
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: CPTH2
• IUPAC标准名: 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazin-1-yl)-1,3-thiazole
• IUPAC传统名: 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazin-1-yl)-1,3-thiazole
• 别名: Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone

产品登记号

• MDL号: MFCD02307488
• CAS号: 357649-93-5

产品性质

• Empirical Formula (Hill Notation): C14H14ClN3S
• 纯度: ≥98% (HPLC)
• 外观: white to beige powder
• 溶解度: DMSO: >10 mg/mL
• 保存温度: 2-8°C
• 德国WGK号: nwg

产品详细信息

详细说明 (English)

Biochem/physiol Actions
CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

详细说明 (简体中文)

Biochem/physiol Actions
CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.