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KR-32568
产品号	K4389	公司名称	Sigma Aldrich
CAS号	852146-73-7	公司网站	http://www.sigmaaldrich.com
分子式	C13H12FN3O2	电话	1-800-521-8956
分子量	261.2516832	传真
纯度	≥98% (HPLC)	电子邮件
保存		Chembase数据库ID: 154026

产品价格信息

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产品别名

标题

KR-32568

IUPAC标准名

N-carbamimidoyl-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide

IUPAC传统名

N-carbamimidoyl-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide

别名

[5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine

产品登记号

CAS号	852146-73-7
PubChem SID	24724522
MDL号	MFCD08705324

产品性质

Empirical Formula (Hill Notation)	C13H12FN3O2
纯度	≥98% (HPLC)
相关基因信息	human ... SLC9A1(6548)
外观	white solid
溶解度	DMSO: ~10 mg/mL
GHS危险品标识
GHS警示词	Warning
GHS危险声明	H302-H315-H319-H335
欧盟危险性物质标志	有害性(Harmful) (Xn)
MSDS下载	下载链接
个人保护装置	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS警示性声明	P261-P305 + P351 + P338
危险公开号	22-36/37/38
安全公开号	26-36
保存温度	2-8°C
德国WGK号	3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC50 = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.

详细说明 (简体中文)

Biochem/physiol Actions
Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC50 = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.