N-methylhistaprodifen 二草酸盐

• 产品号: M7320
• CAS号: 270079-48-6
• 分子式: C25H29N3O8
• 分子量: 499.51306
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: N-Methylhistaprodifen dioxalate salt
• IUPAC标准名: bis(oxalic acid); {2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethyl}(methyl)amine
• IUPAC传统名: bis(oxalic acid); {2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethyl}(methyl)amine
• 别名: N-Methyl-2-[2-(3,3-diphenylpropyl)-1H-imidazol -4-yl]-ethanamine 二草酸盐; N-Methyl-2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]-ethanamine dioxalate salt

产品登记号

• MDL号: MFCD09752603
• CAS号: 270079-48-6

产品性质

• Empirical Formula (Hill Notation): C21H25N3 · 2 C2H2O4
• 纯度: ≥98% (HPLC)
• 外观: white solid
• 溶解度: DMSO: ≥10 mg/mL
• 溶解度: H2O: insoluble <2 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
N-Methylhistaprodifen is more potent than histamine by a factor of 3.5 on guinea pig ileum; more potent than histamine by a factor of 4.3 on guinea pig arterial H1-receptor-mediated vasoconstriction; most potent H1-receptor agonist on the guinea pig ileum out of 17 agonists tested. pEC50 = 7.24 in contraction of guinea pig ileal whole segments; pEC50 = 6.31 in contraction of guinea pig aortic segments. N-methylhistaprodifen does not stimulate H2 and H3 histamine receptors; potential use in the study of H1-receptor-mediated physiological and pathophysiological functions.

详细说明 (简体中文)

Biochem/physiol Actions
N-Methylhistaprodifen is more potent than histamine by a factor of 3.5 on guinea pig ileum; more potent than histamine by a factor of 4.3 on guinea pig arterial H1-receptor-mediated vasoconstriction; most potent H1-receptor agonist on the guinea pig ileum out of 17 agonists tested. pEC50 = 7.24 in contraction of guinea pig ileal whole segments; pEC50 = 6.31 in contraction of guinea pig aortic segments. N-methylhistaprodifen does not stimulate H2 and H3 histamine receptors; potential use in the study of H1-receptor-mediated physiological and pathophysiological functions.