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细胞松弛素 D_分子结构_CAS_22144-77-0)
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细胞松弛素 D

产品号 C2618 公司名称 Sigma Aldrich
CAS号 22144-77-0 公司网站 http://www.sigmaaldrich.com
分子式 C30H37NO6 电 话 1-800-521-8956
分子量 507.61788 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 126841

产品价格信息

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产品别名

标题
Cytochalasin D
IUPAC标准名
(3S,4S,6S,6aR,10S,12R,15R,15aR,15bR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-1H,2H,3H,4H,5H,6H,6aH,9H,10H,11H,12H,15H,15bH-cycloundeca[e]isoindol-15-yl acetate
IUPAC传统名
cytochalasin D
别名
Zygosporin A
松胞菌素 D

产品登记号

MDL号 MFCD00077706
CAS号 22144-77-0
Beilstein号 1632828

产品性质

生物来源 from Zygosporium mansonii
浓度 5 mg/mL in DMSO
Empirical Formula (Hill Notation) C30H37NO6
产品质量级别 PREMIUM
运输包装 wet ice
无菌消毒 0.2 μm filtered
闪点 87 °C
闪点 188.6 °F
MSDS下载 下载链接
个人保护装置 Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
保存温度 -20°C
德国WGK号 2

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.
Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Cytochalasin B is a cell permeable fungal toxin and potent inhibitor of actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It inhibits smooth muscle contraction and insulin-stimulated, but not basal, transport of glucose.
Application
Cytochalasin B is used to inhibit sugar transport in fibroblasts 1, decrease cytoskeletal actin and myosin in rabbit neutrophils 2, and to stimulate B lymphocytes 3. It is a potent inhibitor of actin polymerization, disrupts actin microfilaments, activates the p53-dependent pathways, inhibits smooth muscle contraction, and inhibits insulin-stimulated glucose transport.
详细说明 (简体中文)
Biochem/physiol Actions
肌动蛋白聚合化的强效抑制剂;破坏肌动蛋白微丝;活化 p53 依赖性途径;抑制平滑肌收缩;抑制胰岛素刺激的糖转运。
Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Cytochalasin B is a cell permeable fungal toxin and potent inhibitor of actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It inhibits smooth muscle contraction and insulin-stimulated, but not basal, transport of glucose.
Application
Cytochalasin B is used to inhibit sugar transport in fibroblasts 1, decrease cytoskeletal actin and myosin in rabbit neutrophils 2, and to stimulate B lymphocytes 3. It is a potent inhibitor of actin polymerization, disrupts actin microfilaments, activates the p53-dependent pathways, inhibits smooth muscle contraction, and inhibits insulin-stimulated glucose transport.

参考文献