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SMER28_分子结构_CAS_307538-42-7)
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SMER28

产品号 S8197 公司名称 Sigma Aldrich
CAS号 307538-42-7 公司网站 http://www.sigmaaldrich.com
分子式 C11H10BrN3 电 话 1-800-521-8956
分子量 264.1212 传 真
纯 度 >99% (HPLC) 电子邮件
保 存 Chembase数据库ID: 154014

产品价格信息

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产品别名

标题
SMER28
IUPAC标准名
6-bromo-N-(prop-2-en-1-yl)quinazolin-4-amine
IUPAC传统名
6-bromo-N-(prop-2-en-1-yl)quinazolin-4-amine
别名
6-Bromo-N-2-propenyl-4-quinazolinamine

产品登记号

CAS号 307538-42-7
MDL号 MFCD02166825

产品性质

Empirical Formula (Hill Notation) C11H10BrN3
纯度 >99% (HPLC)
外观 solid
溶解度 DMSO: >20 mg/mL
溶解度 H2O: insoluble
GHS危险品标识 GHS05
GHS危险品标识 GHS07
GHS警示词 Danger
GHS危险声明 H315-H318-H335
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P261-P280-P305 + P351 + P338
危险公开号 37/38-41
安全公开号 26-36/37
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.
详细说明 (简体中文)
Biochem/physiol Actions
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

参考文献