10058-F4

• 产品号: F3680
• CAS号: 403811-55-2
• 分子式: C12H11NOS2
• 分子量: 249.35184
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: 10058-F4
• IUPAC标准名: 5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• IUPAC传统名: 5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 别名: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

产品登记号

• CAS号: 403811-55-2
• MDL号: MFCD00758517

产品性质

• Empirical Formula (Hill Notation): C12H11NOS2
• 纯度: ≥98% (HPLC)
• 外观: yellow solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: <2 mg/mL
• GHS警示词: Warning
• GHS危险声明: H317-H319
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P280-P305 + P351 + P338
• 危险公开号: 36-43
• 安全公开号: 26-36/37
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. It is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 mM using c-Myc transfected Rat1a fibroblasts).

详细说明 (简体中文)

Biochem/physiol Actions
10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. It is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 mM using c-Myc transfected Rat1a fibroblasts).