6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

• 产品号: P5499
• CAS号: 866405-64-3
• 分子式: C24H25N5O
• 分子量: 399.4882
• 纯 度: ≥98% (HPLC)
• 保 存: protect from light

产品别名

• 标题: 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
• IUPAC标准名: 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine
• IUPAC传统名: 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine
• 别名: Dorsomorphin; Compound C; AMPK Inhibitor

产品登记号

• MDL号: MFCD08705402
• CAS号: 866405-64-3
• PubChem SID: 24898658

产品性质

• Empirical Formula (Hill Notation): C24H25N5O
• 纯度: ≥98% (HPLC)
• 外观: white to beige powder
• 溶解度: DMSO: >2 mg/mL (warmed)
• GHS警示词: Warning
• GHS危险声明: H302-H312-H332
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P280
• 危险公开号: 20/21/22
• 安全公开号: 36/37
• 保存条件: protect from light
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. Dorsomorphin also acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase); Ki = 109 nM in the presence of 5 μM ATP and the absence of AMP).

详细说明 (简体中文)

Biochem/physiol Actions
Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. Dorsomorphin also acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase); Ki = 109 nM in the presence of 5 μM ATP and the absence of AMP).