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NS1643

产品号 N0663 公司名称 Sigma Aldrich
CAS号 448895-37-2 公司网站 http://www.sigmaaldrich.com
分子式 C15H10F6N2O3 电 话 1-800-521-8956
分子量 380.2419192 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 153988

产品价格信息

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产品别名

标题
NS1643
IUPAC标准名
1,3-bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
IUPAC传统名
1,3-bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea

产品登记号

CAS号 448895-37-2
PubChem SID 24897438
MDL号 MFCD08705418

产品性质

Empirical Formula (Hill Notation) C15H10F6N2O3
纯度 ≥98% (HPLC)
外观 white to off-white solid
溶解度 DMSO: ≥20 mg/mL
GHS危险品标识 GHS06
GHS警示词 Danger
GHS危险声明 H301-H319
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS警示性声明 P301 + P310-P305 + P351 + P338
RID/ADR UN 2811 6.1/PG 3
危险公开号 22-36
安全公开号 26
保存温度 2-8°C
联合国危险货物等级 6.1
联合国危险货物编号 2811
联合国危险货物包装类别(PG) 3
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
The new diphenylurea compound 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) was tested in hERG channel. In Xenopus laevis oocytes, NS1643 increased both steady-state and tail current at all voltages tested. The EC50 value for hERG channel activation was 10.5 μM. The effect could be reverted by application of the specific hERG channel inhibitor 4′-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide (E-4031) at 100 nM. Application of NS1643 also resulted in a prolonged postrepolarization refractory time. hERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents a new antiarrhythmic approach.
详细说明 (简体中文)
Biochem/physiol Actions
The new diphenylurea compound 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) was tested in hERG channel. In Xenopus laevis oocytes, NS1643 increased both steady-state and tail current at all voltages tested. The EC50 value for hERG channel activation was 10.5 μM. The effect could be reverted by application of the specific hERG channel inhibitor 4′-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide (E-4031) at 100 nM. Application of NS1643 also resulted in a prolonged postrepolarization refractory time. hERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents a new antiarrhythmic approach.

参考文献