黄腐醇 来源于啤酒花 (Humulus lupulus)

• 产品号: X0379
• 分子式: C21H22O5
• 分子量: 354.39638
• 纯 度: ≥96% (HPLC)

产品别名

• 标题: Xanthohumol from hop (Humulus lupulus)
• IUPAC标准名: 1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
• IUPAC传统名: 1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one

产品登记号

• MDL号: MFCD00210576
• PubChem SID: 24902121

产品性质

• Empirical Formula (Hill Notation): C21H22O5
• 纯度: ≥96% (HPLC)
• 外观: powder
• 溶解度: ethanol: soluble10 mg/mL
• 溶解度: DMSO: soluble25 mg/mL
• GHS警示词: Warning
• GHS危险声明: H317-H400
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: Eyeshields, Faceshields, Gloves
• GHS警示性声明: P273-P280
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 43-50/53
• 安全公开号: 22-45-60-61
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Prenylated flavonoids such as xanthohumol have antiproliferative and cytotoxic effects in human cancer cell lines1. Xanthohumol protected HepG2 cells against benzo[a]pyrene and related carcinogens. It also protected against reactive oxygen species (ROS), not by a direct anti-oxidant effect, but instead mediated by induction of cellular defense mechanisms against oxidative stress.2Xanthohumol inhibits diacylglycerol acetyltransferase (DGAT)3 and human P450 enzymes4. It also inhibits the expression of HIF-1α and VEGF under hypoxic conditions5.
Protocols & Applications
Hops (Humulus lupulus) Plant Profile: bioactives, mechanism of action, references

详细说明 (简体中文)

Biochem/physiol Actions
Prenylated flavonoids such as xanthohumol have antiproliferative and cytotoxic effects in human cancer cell lines1. Xanthohumol protected HepG2 cells against benzo[a]pyrene and related carcinogens. It also protected against reactive oxygen species (ROS), not by a direct anti-oxidant effect, but instead mediated by induction of cellular defense mechanisms against oxidative stress.2Xanthohumol inhibits diacylglycerol acetyltransferase (DGAT)3 and human P450 enzymes4. It also inhibits the expression of HIF-1α and VEGF under hypoxic conditions5.
Protocols & Applications
Hops (Humulus lupulus) Plant Profile: bioactives, mechanism of action, references