Bicalutamide (CDX)

• 产品号: B9061
• CAS号: 90357-06-5
• 分子式: C18H14F4N2O4S
• 分子量: 430.3733728
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Bicalutamide (CDX)
• IUPAC标准名: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorobenzenesulfonyl)-2-hydroxy-2-methylpropanamide
• IUPAC传统名: bicalutamide
• 别名: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide; Casodex; Cosudex

产品登记号

• MDL号: MFCD00869971
• CAS号: 90357-06-5

产品性质

• Empirical Formula (Hill Notation): C18H14F4N2O4S
• 纯度: ≥98% (HPLC)
• 外观: powder
• 溶解度: DMSO: >5 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: TX1413500
• 安全公开号: 26
• 保存条件: desiccated
• 保存条件: protect from light
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure antiandrogen. It acts via balancing histone acetylation/deacetylation and recruitment of coregulators. Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF (promyelocytic leukemia zinc finger protein), and GADD45γ (growth arrest and DNA damage inducible, gamma). Bicalutamide (CDX) is inhibited by non-genomic, transcription-independent stimulation of PI3K/AKT phosphorylation by androgens.

详细说明 (简体中文)

Biochem/physiol Actions
Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure antiandrogen. It acts via balancing histone acetylation/deacetylation and recruitment of coregulators. Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF (promyelocytic leukemia zinc finger protein), and GADD45γ (growth arrest and DNA damage inducible, gamma). Bicalutamide (CDX) is inhibited by non-genomic, transcription-independent stimulation of PI3K/AKT phosphorylation by androgens.