利福西亚胺

• 产品号: R9904
• CAS号: 80621-81-4
• 分子式: C43H51N3O11
• 分子量: 785.87854

产品别名

• 标题: Rifaximin
• IUPAC标准名: methyl (7S,11R,12R,13R,14R,15R,16R,17R,18R)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1^4,^7.0^5,^3^5.0^2^6,^3^4.0^2^7,^3^2]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaene-13-carboxylate
• IUPAC传统名: methyl (7S,11R,12R,13R,14R,15R,16R,17R,18R)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1^4,^7.0^5,^3^5.0^2^6,^3^4.0^2^7,^3^2]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaene-13-carboxylate
• 别名: 利福昔明; 4-Deoxy-4′-methylpyrido[1′,2′-1,2]imidazo[5,4-c]rifamycin SV; Rifacol; 4-脱氧-4′-甲基吡啶并[1′,2′-1,2]咪唑并[5,4-c]利福霉素 SV

产品登记号

• CAS号: 80621-81-4
• MDL号: MFCD00864973

产品性质

• Empirical Formula (Hill Notation): C43H51N3O11
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: KD1576000
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Application
Rifaximin is a semisynthetic analog of rifamycin with poor absorptivity. It selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by a mechanism similar to rifabutin, β subunit binding. It is effective against aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is active against species of Staphylococcus, Streptococcus and Enterococcus. It is less active against species of Enterobacteriaceae. Rifaximin is a non-systemic, gastrointestinal site-specific antibiotic. It has a pyridoimidazole ring, making it non-absorbable. Rifaximin is a pregnane X receptor (PXR) activator1.
Biochem/physiol Actions
Rifaximin is a semisynthetic antibiotic used to treat diarrhea caused by E. coli. It is also used to treat hepatic encephalopathy by reducing blood ammonia concentrations. Rifaximin is a potential treatment for inflammatory bowel disease1.

详细说明 (简体中文)

Application
Rifaximin is a semisynthetic analog of rifamycin with poor absorptivity. It selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by a mechanism similar to rifabutin, β subunit binding. It is effective against aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is active against species of Staphylococcus, Streptococcus and Enterococcus. It is less active against species of Enterobacteriaceae. Rifaximin is a non-systemic, gastrointestinal site-specific antibiotic. It has a pyridoimidazole ring, making it non-absorbable. Rifaximin is a pregnane X receptor (PXR) activator1.
Biochem/physiol Actions
Rifaximin is a semisynthetic antibiotic used to treat diarrhea caused by E. coli. It is also used to treat hepatic encephalopathy by reducing blood ammonia concentrations. Rifaximin is a potential treatment for inflammatory bowel disease1.